Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.
نویسندگان
چکیده
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 48 شماره
صفحات -
تاریخ انتشار 2010